| Autor: |
Aron, Hans C. S., Craig, Robert M., Farmer, Chester J., Kendell, H. Worley, Schwemlein, George X. |
| Zdroj: |
Experimental Biology and Medicine; March 1946, Vol. 61 Issue: 3 p271-276, 6p |
| Abstrakt: |
In a study of 92 patients it was found that elevation of the body temperature to 105.5° or 106.0°F (rectal) by physically induced fever was followed by a depression of the plasma vitamin A and carotene. The extent of the depression was directly related to the duration of the fever. The course of the plasma vitamin A and carotene was almost identical irrespective of the chemo-therapeutic agents (bismuth subsalicylate in oil, mapharsen, sulfathiazole or the sodium salt of penicillin) given either before or during physically-induced fever of equal duration. It is, therefore, justifiable to conclude that elevation of the body temperature is the principal cause of the depression of plasma vitamin A and carotene. At the termination of fever, the plasma vitamin A was nearly at the lowest level. The restoration of the plasma vitamin A level usually occurred by the second day after treatment and took place spontaneously without any special medication or dietary measures. The plasma carotene level showed a pattern similar to that of the plasma vitamin A. The depression of the carotene was generally not as great and occurred more slowly. This behavior of the plasma vitamin A is, to the best of our knowledge, the first biochemical indicator shown to serve as a measurement of the intensity of the action of physically-induced fever on the human organism. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
