Acute Anatomic Breakdown of Motor End Plates in Hemorrhagic Shock.∗

Autor: Carey, Eben J., Massopust, Leo C., Zeit, Walter, Haushalter, Eugene, Schmitz, John
Zdroj: Experimental Biology and Medicine; June 1944, Vol. 56 Issue: 2 p115-118, 4p
Abstrakt: The limited evidence in this paper supports the claim that hemorrhagic shock profoundly alters the morphology of the motor end plates and finally produces loss of structural innervation of many muscle fibers in a single voluntary muscle. This histologic change is highly irregular in the different muscles of the rat, therefore large numbers of specimens from different muscles were teased. Gold staining masses of axonic materials drain out into and between the muscle fibers coincident in time with the loss of motor innervation due to the increased permeability of the end plates. The epilemmal axons, exhausted of their substances, are in many places likewise denuded of their hypolemmal end plates. There is therefore a real anatomic breakdown of many motor end plates and histologic alteration of certain skeletal muscles in hemorrhagic shock.
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