| Abstrakt: |
White, Heinbecker and Rolf1reported that removal of the glandular division of the hypophysis in dogs resulted in a reduction of 50% or more in inulin and diodrast clearances and in maximal tubular excretion of diodrast at high plasma levels. These changes indicate a depression of renal blood flow and of renal tubular excretory capacity and were in evidence within 7 days after the removal of the glandular hypophysis. They have persisted under observation for a period of 2 years. It can be stated, therefore, that the glandular hypophysis exercises a humoral influence on the kidney. Evidence that the eosinophile cells of the hypophysis are responsible for this influence is presented in this paper.Observations on the urea clearance of 5 patients with acromegaly revealed values of 130, 83, 135, 231, and 100%, respectively, of the normal standard. Three of these values are definitely above the upper limit of normal. An eosinophil tumor was found at autopsy in the first of these patients. The kidneys weighed 420 g. Microscopically the glomeruli and tubules were slightly hypertrophied. There was generalized arteriosclerosis of the renal vessels. Some increase in kidney size is a usual finding in acromegaly. Since eosinophil cell hyperplasia or eosinophil tumor formation has been found in all cases of acromegaly2coming to autopsy, the increase in renal function and in renal size observed in this disease perhaps may be attributed to hyperfunction of the eosinophil cells of the glandular hypophysis. The degree of secretory activity of the hypophysial tumor should be reflected in the extent of increase in renal function.Winternitz and Waters3and White, Heinbecker and Rolf4have shown that in dogs a single remaining kidney fails to hypertrophy after removal of the glandular division of the hypophysis. |
