Abstrakt: |
Application of the technic described, considering tissue toxicity as well as germicidal power, indicates that in general the chlorine compounds rate the highest, phenolic compounds next, and organic mercurials rate the lowest as efficient germicides. This corroborates certain previous studies.4, 8, 9Tincture preparations in general are not ideal germicides since the solvents are more toxic to phagocytosis than to bacteria.The toxicity and germicidal end points found in this study indicate that a large number of germicides in general use are too concentrated. Germicides should be utilized in concentrations which are germicidal but non-toxic to tissue. The efficiency range is defined.Of the natural barriers to infection, i. e., skin and blood, the blood is more sensitive to the destructive action of germicides. Therefore the phagocytosis inhibition technic may be regarded as a valuable aid in the evaluation of germicides for clinical use. |