| Autor: |
Soloway, David, Hansen, Lorenz P., McCahey, James F. |
| Zdroj: |
Experimental Biology and Medicine; June 1939, Vol. 41 Issue: 2 p547-551, 5p |
| Abstrakt: |
(1) Sesame oil is not absorbed (at least within 188 hours) beyond the stratum corneum of the epidermis of the capon comb, following surface application of the oil alone or the oil acting as a vehicle for androgens. (2) Urinary androgens are selectively absorbed from sesame oil at the inner margin of the stratum corneum, then rapidly penetrate to induce characteristic growth changes. (3) The ability of crude urinary extracts used in these experiments to penetrate the barrier of the epidermis and spread in the dermal and subdermal tissues is similar to the spreading effects of intradermally injected testicular extracts. (4) The greater growth reaction in the comb due to percutaneous applications as compared with parenteral administration of the same androgenic material, appears to be a matter of rate of absorption more nearly approaching the normal physiological requirements of the bird. This involves a gradual and adequate separation of the hormone from the oil, a rapid penetration of the rest of the epidermis and dermis and a large dermal network of capillaries, present even in the capon crest.The authors wish to thank Professor J. Parsons Schaeffer for his interest and aid in this work and Dr. John Franklin Huber for helpful criticism. |
| Databáze: |
Supplemental Index |
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