| Autor: |
Master, Arthur M., Gubner, Richard, Dack, Simon, Jaffe, Harry L. |
| Zdroj: |
Experimental Biology and Medicine; May 1939, Vol. 41 Issue: 1 p89-94, 6p |
| Abstrakt: |
Infarction of the heart following coronary artery occlusion is attended by a profound disturbance in the circulation. While the circulatory dynamics and electrocardiographic changes have been extensively investigated, very little attention has been paid to direct observation of alterations in cardiac contraction.That experimental ligation of a coronary artery interferes with the orderly contraction of the ventricles has been known since the 17th century.12A detailed description of the changes in ventricular contraction, however, has been lacking until the recent investigation of Tennant and Wiggers.3Employing the myocardiograph, these authors found that immediately after occluding branches of the coronary arteries in dogs the area of muscle rendered ischemic ceased to contract and paradoxical (reverse) movements occurred, i. e.,the ischemic area bulged passively while the remainder of the ventricle contracted normally.There have been few recorded fluoroscopic observations in man of the effect of coronary artery occlusion on the contractile movements of the heart, even in cases where the infarct is so extensive as to result in the formation of a ventricular aneurysm.456Zadek,7and Levene8observed localized impairment of contraction of the left ventricle in coronary artery disease but did not describe systolic expansion (reversal of pulsation) which was a characteristic finding in the studies of Tennant and Wiggers on dogs.The movements of the left ventricle in 64 cases of myocardial infarction due to coronary artery occlusion have been studied by fluoroscopy at intervals varying from one month to 4 years after the acute attack. The findings were compared with roentgenkymograms which were taken immediately after fluoroscopy. In addition cineroentgenographic studies were carried out in a group of 24 subjects with normal hearts and with cardiac infarcts. |
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