| Autor: |
Harkins, Henry N., Harmon, Paul H. |
| Zdroj: |
Experimental Biology and Medicine; October 1934, Vol. 32 Issue: 1 p178-181, 4p |
| Abstrakt: |
Attempts were made in these experiments to compare the minimal fatal dose of air and oxygen when introduced into a peripheral vein. Van Allen, Hrdina and Clarke1found that in embolism due to air introduced into the pulmonary vein, the rapidity of introduction of the air and the position of the animal were 2 factors of prime importance. The position of the animal was believed to be of importance by directing the flow of air upward by gravity. These authors found that when the head was uppermost, the air more easily produced death. In embolism due to introduction of air into a peripheral vein, the air goes first to the heart and lungs independent of the position of the animal. In the present studies, all animals were kept flat in the supine position during the injection of gas. The gas was injected quite rapidly; in most instances the entire amount being introduced in about 30 seconds.The minimal fatal dose of air was found to be about 8 cc. per kilo body weight. Animals under urethane anesthesia were used throughout the work. The air was injected through a large cannula into the femoral vein (usually the left) from an inverted burette, being forced in by a column of water. Another cannula was placed in the carotid artery to record the blood pressure. The air flowed in rapidly until at a certain point it began to flow more slowly and the column of water showed pulsations synchronous with the heart beat. This usually occurred when very roughly nine-tenths of the minimal fatal dose was injected. The results of 11 air injections are shown in Table 1. |
| Databáze: |
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| Externí odkaz: |
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