| Abstrakt: |
The reactions described here bear a relationship to the subject of nonspecific protein therapy although there is no intention at this time to consider this phase of the subject. In connection with the study of nonspecific protein reactions, many observations have been reported upon the leucocytic response especially in the human being, and particularly following the intravenous injection of B. typhosus.A full review is given by Petersen.1Ling2reported various blood reactions both in the human and in the rabbit, employing several substances for injection, including milk, peptone, horse serum and B. typhosus.Most of the injections were administered intravenously. He obtained only a very slight response in his leucocytic reactions.We wish to report the comparative leucocytic reactions produced in the rabbit by the subcutaneous, intraperitoneal and intravenous routes of injection for 8 different substances.Twenty-four full grown rabbits, chiefly males, were used and the following antigens employed: Cysteine, peptone, globulin, market milk, Staphylococcus aureus, Streptococcus hemolyticus, B. typhosusand the supernatant portion of a sero-purulent exudate obtained from a streptococcal arthritis. The latter was centrifugalized and the supernatant portion used as such and also after filtration through a Seitz filter. The unfiltered portion was found to contain a few scattered chains of living streptococci. |
