| Abstrakt: |
Adenine, guanine, hypoxanthine and xanthine were fed at intervals to two subjects living on a constant purine-free diet. The effects of the administration of these purines (1 to 1.5 grams) on various metabolic functions, especially the partition of nitrogen in the urine, was reported. The output of urinary purines is summarized here: From the numerous data reported, the authors conclude that all of the familiar purines may lead to an increase in exogenous uric acid in the urine of man, with (quantitatively) little influence on the elimination of purine bases. In contradiction to the recent suggestion of Plimmer, Dick, and Leib,1they interpret their protocols to support the view that uric acid is a stage in the metabolism of exogenous purines, rather than an expression of leucocyte metabolism. |
