| Autor: |
Blankestijn, PeterJ., Tulen, Joke, Boomsma, Frans, Ritsema Van Eck, H.J., Mulder, Paul, MAN IN'T VELD, ArieJ., Van Den Meiracker, A.H., Moleman, Peter, Derkx, FransH.M., Lamberts, StevenJ., Schalekamp, MaartenA.D.H. |
| Zdroj: |
The Lancet; December 1988, Vol. 332 Issue: 8625 p1386-1389, 4p |
| Abstrakt: |
In a double blind, crossover study 6 h infusions of adrenaline (15 ng/kg/min; 1 ng=5·458 pmol), noradrenaline (30 ng/kg/min; 1 ng = 5·911 pmol), and a 5% dextrose solution (5·4 ml/h), were given to ten healthy volunteers in random order 2 weeks apart. By means of intra-arterial ambulatory monitoring the haemodynamic effects were followed for 18 h after the infusions were stopped. Adrenaline, but not noradrenaline, caused a delayed and protracted pressor effect. Over the total postinfusion period systolic and diastolic arterial pressure were 6 (SEM 2)% and 7 (2)%, respectively, higher than after dextrose infusion (ANOVA, p<0·001). Thus, "stress" levels of adrenaline (230 [28] pg/ml) for 6 h cause a delayed and protracted pressor effect. These findings are strong support for the adrenaline-hypertension hypothesis in man. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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