| Autor: |
Rubio, Rosa M., Depledge, Daniel P., Bianco, Christopher, Thompson, Letitia, Mohr, Ian |
| Zdroj: |
Genes & Development; 2018, Vol. 32 Issue: 23-24 p1472-1484, 13p |
| Abstrakt: |
In this study, Rubio et al. researched how the dynamic genome-wide landscape of m6A-modified mRNAs impacts virus infection and host immune responses. They show that type I interferon (IFN) production triggered by dsDNA or human cytomegalovirus (HCMV) is controlled by the cellular m6A methyltrasferase subunit METTL14 and ALKBH5 demethylase, and their results demonstrate that responses to nonmicrobial dsDNA in uninfected cells are regulated by enzymes controlling m6A epitranscriptomic changes. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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