ARTIFICIAL SWEETENERS AND HUMAN BLADDER CANCER

Autor: Howe, G.R, Burch, J.D, Miller, A.B, Morrison, B, Gordon, P, Weldon, L, Chambers, L.W, Fodor, G, Winsor, G.M
Zdroj: The Lancet; September 1977, Vol. 310 Issue: 8038 p578-581, 4p
Abstrakt: A positive association between the use of artificial sweeteners, particularly saccharin, and risk of bladder cancer in males has been observed in a case-control study of 480 men and 152 women in three Provinces in Canada. The risk ratio for ever versus never used is 1·6 for males (p=0·009, onetailed test), and a significant dose-response relationship was obtained for both duration and frequency of use. The population attributable risk for males is estimated at 7%, though for diabetics, who have a similar risk ratio for artificial sweetener use as non-diabetics, the attributable risk is 33%.
Databáze: Supplemental Index