| Autor: |
Babu, Jacob V., Popay, Alison J., Miles, Christopher O., Wilkins, Alistair L., di Menna, Margaret E., Finch, Sarah C. |
| Zdroj: |
Journal of Agricultural and Food Chemistry; December 2018, Vol. 66 Issue: 50 p13116-13125, 10p |
| Abstrakt: |
New compounds, 11,12-epoxyjanthitrem B (1) and 11,12-epoxyjanthitrem C (4), were isolated from Penicillium janthinellumand given the trivial names janthitrem A and janthitrem D, respectively. The known compounds janthitrem B (2) and janthitrem C (3) were also isolated, and NMR assignments were made for all four compounds. This showed that the previously published NMR assignments for 3needed considerable revision. 1and 2were used as model compounds for the more complex, and highly unstable, epoxyjanthitrems that have been isolated from perennial ryegrass infected with the AR37 endophyte and which contain an epoxide group analogous to that of 1. Both 1and 2induced tremors in mice and reduced weight gain and food consumption of porina (Wiseana cervinata) larvae, although 1showed greater potency. This shows the importance of the epoxy group and suggests that epoxyjanthitrems are likely to be involved in the observed effects of the AR37 endophyte on livestock and insects. |
| Databáze: |
Supplemental Index |
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