| Autor: |
Crow, James W., Gibaldi, Milo |
| Zdroj: |
The Annals of Pharmacotherapy; October 1978, Vol. 12 Issue: 10 p612-616, 5p |
| Abstrakt: |
A method to characterize the pharmacokinetics of a drug in a patient receiving it chronically is proposed. In principle, such characterization may be carried out by obtaining one or more drug concentration in plasma-time values from several differentdosing intervals, combining the data to create a composite dosing interval representative of the steady-state situation and fitting the data to an appropriate equation. The method was evaluated using simulated data based on the average pharmacokinetic parameters of theophylline in children. Reasonable estimates of the elimination rate constant and apparent volume of distribution may be obtained, but the estimation of the absorption rate constant presents formidable problems. The method appears to be most useful for obtaining very accurate estimates of total clearance. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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