| Autor: |
Greenwald, Stephen E., Letts, L.Gordon, Newman, David L., Piper, Priscilla J. |
| Zdroj: |
European Journal of Pharmacology; August 1984, Vol. 103 Issue: 1-2 p107-114, 8p |
| Abstrakt: |
Coronary, femoral and carotid vascular beds of anaesthetised pigs were perfused with heparinised arterial blood using an extracorporeal perfusion system. Blood flow was measured in each vascular bed. Leukotriene (LT) D4caused a dose-related reduction in flow in the left anterior descending (LAD) artery. LTs C4and D4, angiotensin and noradrenaline caused dose-related reductions in flow in femoral and carotid vascular beds. High doses of LTD4caused total cessation of blood flow in the LAD and femoral beds. In the femoral and carotid beds LTC4but not LTD4caused an initial increase followed by a prolonged reduction in flow. Indomethacin (1.4×10−5mol kg−1, i.v.) did not affect the vasoconstrictor action of LTs. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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