| Abstrakt: |
Several facts have pointed to the possibility that certain actions of growth hormone preparations (STH) are antagonistic to those of 11-oxysteroids (Marx et al., 1943). A suppressing action of cortisone upon granulation tissue formation has been reported following its local (Baker & Whitaker, 1948; Castor & Baker, 1950; Meier et al., 1950) and systemic administration (Ragan et al., 1949 a, b). STH was reported to stimulate the formation of granulation tissue about turpentine abscesses in presence or absence of cortisone (Taubenhaus et al., 1952). Using granuloma-pouch technique, it was shown that pretreatment with STH augments resistance of adjacent skin to necrotizing action of croton oil, while cortisol has an opposite effect. In simultaneous treatment with STH and cortisol, the protective action of the former is abolished by the latter hormone (Selye, 1954). Similar findings were made using the cotton plug technique (Stebbins & Stoerk, 1954). In view of the lack |
