THE EFFECT OF HEXAMETHONIUM CHLORIDE ON THE EOSINOPENIC RESPONSE DURING STRESS IN RATS

Autor: Louwerens, B., Smelik, P. G.
Zdroj: European Journal of Endocrinology; September 1953, Vol. 14 Issue: 1 p27-32, 6p
Abstrakt: The mechanism of control of the adreno-cortical function is still an unsolved problem. Longand his associates repeatedly stressed the important role of epinephrine in this mechanism, by showing that this substance acts directly on the adeno-hypophysis (Long & Fry, 1945; McDermott et al., 1950 a). McDermott et al.(1950 b) advanced the hypothesis that reflex secretion of epinephrine must be considered as the first phase – the »autonomic« phase – of the above mentioned mechanism. This is followed by a so-called »metabolic« phase, as described by Sayers & Sayers(1948), during which the secretion of ACTH by the pituitary gland depends on the level of Adrenal Cortical Hormone (ACH) in the blood.If epinephrine is to be considered as a physiological intermediate in the mechanism of control of the adrenal cortex, it may be expected that this action can be prevented by autonomic blocking agents. Therefore several workers investigated
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