| Autor: |
Fischer, F., Friis-Hansen, B., Georg, J., Hastrup, B., Kalbak, K., Sprechler, M., Warming-Larsen, Aa., Wulff, H. |
| Zdroj: |
European Journal of Endocrinology; August 1953, Vol. 13 Issue: 4 p293-305, 13p |
| Abstrakt: |
In recent years the employment of preparations of ACTH with delayed absorption (»retard preparations«) has become more common, chiefly for practical reasons, as the frequent injections during the 24 hours may thus be avoided and replaced by a single dose. Among the more common »retarding« principles the following have been mentioned: adsorption of ACTH to colloid metal compounds (sometimes in gelatin or polyvinylpyrrolidone), suspension in oil or wax, or the preparation of a zinc protamine ACTH-complex.Hamburger(1952) demonstrated that nearly 95–98 % of the ACTH injected intramuscularly was inactivated in the musculature itself. If this destructive process could be prevented, it would be reasonable to expect a prolonged as well as an intensified effect of the ACTH preparation. In experiments with an unspecific enzyme inhibitor – polyphloretin phosphate(POFF) – Högberg, Johnsson & Waldenström(1952) and, later, Hamburger(1952), and Warming-Larsen, Hamburger & Sprechler(1952) were able to |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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