| Abstrakt: |
Clinical Research Centre, Watford Road, Harrow, Middlesex HA 1 3 UJ(Received 3rd March 1974)A common immunological consequence of pregnancy is that the mother may become sensitized to fetal or paternal antigens (Goodlin & Herzenberg, 1964; Kaliss & Dagg, 1964; Soren, 1967). Recently, Maroni & Parrott (1973) have demonstrated that cell-mediated immunity against paternal antigens increases with parity. We have attempted to compare the results of normal parity with artificial immunization designed to simulate maternal sensitization to paternal antigens.Outbred TO mice, of approximately the same age (6 to 7 weeks), conventionally housed at the M.R.C. Clinical Research Centre, were used in this study. Two groups of mice were investigated: (1) a group of parous mice which had been mated so that they reached their final parities at approximately the same age (29 to 34 weeks) ; (2) a group of virgin females which had been sensitized to sensitized |
