| Autor: |
EDGREN, R. A., CALHOUN, D. W. |
| Zdroj: |
Journal of Endocrinology; June 1960, Vol. 20 Issue: 4 p325-330, 6p |
| Abstrakt: |
Studies on spayed rats treated simultaneously with mixtures of oestrone and oestriol showed that at low dose levels of oestrone the minor uterine growth response produced is augmented by oestriol; at intermediate doses of oestrone the response is inhibited by oestriol. Large doses of oestrone appear to be unaffected. 16-Epioestriol would appear to show a somewhat similar pattern of activities. We believe that these data suggest that oestriol, and perhaps 16-epioestriol, may act as a sort of biological buffer for the stronger oestrogens, maintaining the uterus when titres of the stronger oestrogens are low, restricting their actions when they are relatively high. |
| Databáze: |
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| Externí odkaz: |
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