| Abstrakt: |
Adult female albino rats of the Sprague-Dawley strain were ovariectomized or sham-operated and tested for their susceptibility to audiogenic seizures at regular intervals after operation. The animals were given daily injections of hormones (testosterone, progesterone, or oestradiol) at different dose levels. A total of 372 animals, divided into twenty-six groups according to initial seizure susceptibility and treatment, were used. The results showed that, in the seizure-resistant animals, ovariectomy did not significantly alter the incidence of audiogenic seizures. Testosterone and progesterone produced a significant increase in seizure susceptibility in the sham-operated group only. Oestradiol significantly increased seizure incidence in both operated groups. In the seizure-susceptible animals (ovariectomized and sham-operated) all hormones produced significant decreases in seizure incidence. Of the three hormones, testosterone produced the most marked decrease in seizures, followed by progesterone and, finally, oestradiol. |
