| Autor: |
Neher, R., Kahnt, F. W., Roversi, G. D., Bompiani, A. |
| Zdroj: |
European Journal of Endocrinology; June 1965, Vol. 49 Issue: 2 p177-192, 16p |
| Abstrakt: |
Cryptorchid testicular and testicular adenoma tissue obtained from two patients with the testicular feminisation syndrome was incubated with 3Hor 14C-labelled pregnenolone, 17-hydroxy-pregnenolone, progesterone and androstenedione. In the tissue of both patients a similar steroid transformation pattern was observed.There was abundant biosynthesis of testosterone from androstenedione but rather little from the other precursors. Oestrone and oestradiol were formed only from androstenedione. There is ample evidence of both 17-hydroxylation and side-chain splitting, in particular with the δ5-precursors. From the ratio of the δ5- and δ4-steroids identified, it is concluded that there was, however, little dehydrogenation of the 3β-hydroxyl group.Though there seems to be no qualitative difference as compared with what is known about the possible pathways in testicular tissue from various species, our findings contrast to some extent with those reported previously by other investigators in a few cases of testicular feminisation. The possible role of anti-androgens is discussed. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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