Effect of somatostatin on growth hormone and prolactin response to dermorphin in man

Autor: Uberti, E. C. degli, Trasforini, G., Salvadori, S., Margutti, A., Teodori, V., Rotola, C., Tomatis, R., Pansini, R.
Zdroj: European Journal of Endocrinology; January 1985, Vol. 108 Issue: 1 p20-25, 6p
Abstrakt: Abstract. The effects of iv somatostatin (somatotrophin release inhibiting factor (SRIF)) on growth hormone (GH) and prolactin (Prl) response to dermorphin (D) were tested in 6 healthy men. In all subjects D induced a significant increase in GH and Prl levels, as expected. SRIF completely blocked the GH-releasing activity of D, whereas it only reduced the Prl-releasing activity.The results confirm that D is a potent stimulant for GH and Prl release in man, and furthermore demonstrate that the action of D on GH secretion can be completely overridden by SRIF.
Databáze: Supplemental Index