| Autor: |
Wahab, I F, Zailani, N, Razak, S I A, Nayan, N H M |
| Zdroj: |
IOP Conference Series: Materials Science and Engineering; October 2018, Vol. 440 Issue: 1 p012043-012043, 1p |
| Abstrakt: |
Recent years have witnessed a huge growth of research in pharmaceutical sciences using nanoparticles as drug transport to reduce toxicity and for more specific drug targeting. Conventional application of drugs has major limitation and drawback since they have limited effectiveness, unsustainable release, and poor biodistribution. Thus this paper aims to produce a suitable material loaded with drugs that can provide an efficient effect of the drug at the site of action and maintain them throughout the treatment. Halloysite nanotubes were used as the material since it fulfills all the criteria needed for sustained drug release. Here, benzalkonium chloride was used as an antiseptic along with methylene blue and methyl orange as the cationic and anionic drug models. All three drugs were loaded into the halloysite lumen by vacuum suction. Result shows the most successful loading efficiency is halloysite loaded with methyl orange where the loading is almost 82% and also shows an excellent sustained release for 19 hours when released in 0.3M hydrochloric acid. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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