| Autor: |
Domańska-Senderowska, D, Snochowska, A, Szmigielska, P, Jastrzębski, Z, Jegier, A, Kiszałkiewicz, J, Dróbka, K, Jastrzębska, J, Pastuszak-Lewandoska, D, Cięszczyk, P, Maciejewska-Skrendo, A, Zmijewski, P, Brzeziańska-Lasota, E |
| Zdroj: |
Balkan Journal of Medical Genetics; October 2018, Vol. 21 Issue: 1 p19-25, 7p |
| Abstrakt: |
The PPARDgene codes protein that belongs to the peroxisome proliferator-activated receptor (PPAR) family engaged in a variety of biological processes, including lipid metabolism in muscle cells. In this study, we assess the relationship between PPARDgene expression lipid metabolism parameters and the variation of the PPARDgene expression before (T1) and after 12 hours of training (T2) sessions in a group of football players. Peripheral blood lymphocytes were obtained from 22 football players (17.5±0.7 years, 178±0.7 cm, 68.05±9.18 kg). The PPARDgene expression, analyzed by quantitative polymerase chain reaction (qPCR), was significantly higher after T2(p= 0.0006). Moreover, at the end of the training cycle, there was a significant decrease in relative fat tissue (FAT) (%) (p= 0.01) and absolute FAT (kg) (p= 0.01). A negative correlation was observed between absolute FAT (kg) and PPARDgene expression level in T2(p= 0.03). The levels of cholesterol and triglyceride (TG) fractions were not significantly different (p>0.05) before and after training. No significant relationship between PPARDexpression and cholesterol or TG levels was found. We found that physical training affects PPARDexpression. Moreover, the negative correlation between PPARDexpression and absolute FAT (kg) level may be indicative of the contribution of PPARDin metabolic adaptation to increased lipid uptake that can be used to control the body composition of athletes. |
| Databáze: |
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