| Autor: |
Siersbæk-Nielsen, K., Kirkegaard, C., Rogowski, P., Faber, J., Lumholtz, B., Friis, Th. |
| Zdroj: |
European Journal of Endocrinology; January 1978, Vol. 87 Issue: 1 p80-87, 8p |
| Abstrakt: |
A possible extrathyroidal effect of propylthiouracil (PTU) and carbimazole on serum levels of thyroxine (T4), triiodothyronine (T3), 3,3′,5′-triiodothyronine (reverse T3) and on thyrotrophin-releasing hormone (TRH) induced thyrotrophin (TSH) release was estimated in 19 patients with severe hypothyroidism treated with T4. During PTU medication a significant decrease in serum T3from 90 ± 16 (sd) to 79 ± 23 ng/100 ml (P< 0.01) and a reciprocal increase in serum reverse T3from 51 ± 14 (sd) to 58 ± 20 ng/100 ml (P< 0.025) were found. No significant changes in serum T4, basal serum TSH or response to TRH could be demonstrated. Carbimazole did not change any of the parameters studied. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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