| Autor: |
Fukunishi, H., Mickan, H., Zander, J. |
| Zdroj: |
European Journal of Endocrinology; September 1975, Vol. 80 Issue: 1 p138-148, 11p |
| Abstrakt: |
Nine human ovaries were perfused in vitrowith [4-14C] progesterone and in addition one ovary with [7-3H] pregnenolone. From the perfusate unchanged progesterone and five different metabolites were isolated: 20α-dihydroprogesterone, 17α-hydroxyprogesterone, 16α-hydroxyprogesterone, 5α-pregnane-3,20-dione and 4-androstene-3,17-dione. In the ovarian tissue saturated pregnane derivatives were the main metabolites.When [3H] pregnenolone and [14C] progesterone were perfused simultaneously a stimulation of Δ4–5-isomerase and 3β-dehydrogenase activity by HCG was demonstrated. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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