| Abstrakt: |
Many findings in our previous investigations (Parviainen et al., 1949, 1950 a - h, 1951 a - g) seemed to suggest that cortisone might eventually be of some use in the treatment of late toxaemia of pregnancy. The earlier (e. g. Soffer, 1949) supposed capacity of cortisone to increase sodium excretion and its inhibiting effect on the pathological changes produced by desoxycorticosterone acetate (Selye, 1950 a - b, Woodbury, Rosenberg & Sayers, 1950), and further, its possible beneficial effect in some cases of nephrosis (Deming & Luetscher, 1950) and in hypertension (Perera et al., 1944 - 1950) seemed to us to be of value in toxaemia, when this disease appeared as a syndrome of hyperadaptation to the stress of pregnancy (Parviainen et al., 1949).Since the mode of action of cortisone and its true effects have not yet been sufficiently explained ( e. g. according to the review of Ingle, 1950), we decided to study |
