| Autor: |
Daniels, H., van Amstel, W. J., Schopman, W., van Dommelen, C. |
| Zdroj: |
European Journal of Endocrinology; November 1963, Vol. 44 Issue: 3 p346-354, 9p |
| Abstrakt: |
The effect of metopirone® (SU-4885)* in a patient with metastatic adrenal cortical carcinoma was studied. The intention was to depress the symptoms of Cushing's syndrome, due to a high glucocorticoid production by the carcinoma.The excretion of 17-KS, 17-KGS, 11-oxo(y)-17-OHCS and 11-desoxy-17-OHCS was followed for seven weeks.The steroid excretion was variable. The 11-oxo(y)-17-OHCS showed a significant decrease during treatment with SU-4885 for seven weeks. The ratio 11-oxo(y)-17-OHCS: 11-desoxy-17-OHCS fell from 1.7 to 0.1 during this period.The excessive glucocorticoid production of the metastatic adrenal carcinoma was suppressed as long as treatment continued.It was not possible to judge the clinical effect of SU-4885 because of the progressive nature of the disease. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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