| Autor: |
Song, Hua, Seishima, Mitsuru, Saito, Kuniaki, Maeda, Satoshi, Takemura, Masao, Noma, Akio, Kondo, Akira, Manabe, Mitsuhisa, Urakami, Katsuya, Nakashima, Kenji |
| Zdroj: |
Annals of Clinical Biochemistry; May 1998, Vol. 35 Issue: 3 p408-414, 7p |
| Abstrakt: |
It has been demonstrated that apolipoproteins found in cerebrospinal fluid (CSF) play an important role in lipid metabolism in the central nervous system (CNS). Previously we reported that CSF apo A-I levels increased with the severity of neurological damage in poliovirus-infected macaques. In the present study, apo A-I was quantitatively analysed in CSF from patients with or without neurological diseases. In controls, CSF apo A-I level was significantly higher in males; 3·83 (0·40) mg/L, mean (SEM) (n= 19) compared with females, 2·42 (0·26) mg/L (n= 23, P< 0·05). CSF apo A-I concentrations in patients with acute meningitis increased at the active stage, 7·74 (1·78) mg/L (n= 10), but returned to basal concentrations at the convalescent stage 2·72 (0·38) mg/L (n= 10), while the CSF apo A-I level in patients with other neurological diseases remained in the same range as in controls. By contrast, CSF apo E was consistently elevated at either stage of acute meningitis. Furthermore, it was found that the levels of CSF apo A-I, but not of apo E, correlated positively with CSF albumin concentrations. These findings suggest that the CSF apo A-I and apo E have different origins and may play different roles in the lipoprotein metabolism in CNS. |
| Databáze: |
Supplemental Index |
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