| Autor: |
Mak, T W L, Ho, S S, Ho, C S, Jones, M G, Lai, C K W, Lam, C W K |
| Zdroj: |
Annals of Clinical Biochemistry; January 1998, Vol. 35 Issue: 1 p94-98, 5p |
| Abstrakt: |
Pseudouridine in urine and plasma has been proved to be a useful tumour marker in many malignant conditions. We studied its usefulness in pleural fluid for distinguishing malignant from non-malignant pleural effusions.Pleural fluid pseudouridine concentrations in different groups of patients with pleural effusion (31 malignant, 29 benign, 16 unknown, 1 double pathology) was measured and compared. Its usefulness in distinguishing malignant from non-malignant pleural effusions was analysed by receiver-operating characteristic (ROC) curve analysis.Pseudouridine concentrations in the malignant group were significantly higher than the non-malignant group (P< 0.017, Bonferroni adjustment) with values overlapping extensively at the lower end. The area-under-the curve (AUC) value in the ROC curve analysis was 0.675 (P< 0.05).We conclude that the pleural fluid pseudouridine is of limited clinical value in distinguishing malignant from non-malignant pleural effusion due to its extensive overlap. However, it is useful when the concentration is higher than 65 μmol/L, which indicates malignancy. |
| Databáze: |
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