| Autor: |
Burdon, R.H., Gill, Vera, Boyd, Patricia A., Rahim, Raha Abdul |
| Zdroj: |
FEBS Letters; April 1996, Vol. 383 Issue: 3 p150-154, 5p |
| Abstrakt: |
Exposure of HeLa cells in monolayer culture to increasing concentrations of exogenously added H2O2causes damage to cellular DNA. When the DNA is subsequently isolated from the non‐apoptotic cells remaining in such cultures, evidence was obtained to suggest that the DNA damage elicited in intact cells was non‐random and that certain nucleotide sequences associated with, or related to, the genes for heat shock protein 60 and catalase were more susceptible to damage than others. In contrast, these particular sequences were not specifically susceptible to damage when naked human DNA was exposed directly to H2O2in vitro. On an overall comparative basis, sequences in the genes encoding catalase, α‐1 antitrypsin and β‐actin appear more vulnerable to H2O2in vivo, than sequences in H‐rasand the p53 gene which seem surprisingly resistant. |
| Databáze: |
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