| Autor: |
Brivet-Chevillotte, Paule, di Rago, Jean-Paul |
| Zdroj: |
FEBS Letters; September 1989, Vol. 255 Issue: 1 p5-9, 5p |
| Abstrakt: |
The yeast box‐mutant W7 exhibits deficiencies in cytochrome band in nuclear coded complex III subunits, a phenotype observed previously in a patient with mitochondrial myopathy. DNA sequence analysis of mutant W7 revealed a single base transition in the cytochrome bgene; the mutated residue Gly 131 is perfectly conserved in all known cytochromes band belongs to the Q0domain. Mutant W7 provides a model system for evaluating the action of therapeutic agents, such as vitamin K3which restored NADH‐oxidase activity in the mutant as well as in the antimycin‐inhibited wild type. However, with the mutant, a greater quantity of menadione was necessary due to a decrease in other complex activities, and a much lower electron‐flow fraction passed through cytochrome oxidase. |
| Databáze: |
Supplemental Index |
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