Anthraquinone inhibitors of photosystem II electron transport

Autor: Oettmeier, Walter, Masson, Klaus, Donner, Andreas
Zdroj: FEBS Letters; April 1988, Vol. 231 Issue: 1 p259-262, 4p
Abstrakt: Various substituted 9,10‐anthraquinones were tested for their inhibitory activity on photosystem II electron transport. Maximal inhibitory activity was achieved if the positions adjacent to one of the quinone carbonyl groups were unsubstituted or substituted by hydroxyl groups only. The best anthraquinone type inhibitor found so far was 2,3,4‐trichloro‐1‐hydroxy‐anthraquinone with a pI50value of 7.75. This is well comparable to the most powerful known photosystem II inhibitors. As studied by binding experiments with 1‐[14C]methoxy‐anthraquinone, after covalent modification of thylakoids with azido‐atrazine, anthraquinones bind at the photosystem II D1 protein. Their orientation within the binding niche seems to be different from that of other photosystem II inhibitors.
Databáze: Supplemental Index