| Autor: |
Palm, Dieter, Münch, Gerald, Malek, Daria, Dees, Christian, Hekman, Mirko |
| Zdroj: |
FEBS Letters; February 1990, Vol. 261 Issue: 2 p294-298, 5p |
| Abstrakt: |
Competition between Gs‐protein and the synthetic peptide, GSA 379‐394, derived from the carboxyl‐terminal region of the αs‐subunit, led to complete inhibition of receptor‐mediated adenylate cyclase activation in turkey erythrocyte membranes. Related peptides corresponding to the homologous carboxyl‐terminal region of αt‐,αil‐ or αo‐subunits did not interfere with β‐receptor‐Gscoupling. The direct coupling between Gsand adenylate cyclase was not influenced by any of these peptides. These results emphasize the important role of the carboxyl‐terminus of G‐protein α‐subunits for the specific recognition of their corresponding receptors and for signal transduction. |
| Databáze: |
Supplemental Index |
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