| Autor: |
Stapleton, David, Woollatt, Erica, Mitchelhill, Ken I, Nicholl, Jillian K, Fernandez, C.Shamala, Michell, Belinda J, Witters, Lee A, Power, David A, Sutherland, Grant R, Kemp, Bruce E |
| Zdroj: |
FEBS Letters; June 1997, Vol. 409 Issue: 3 p452-456, 5p |
| Abstrakt: |
The AMP‐activated protein kinase (AMPK) consists of catalytic α and non‐catalytic, β and γ (38 kDa) subunits and is responsible for acting as a metabolic sensor for AMP levels. There are multiple genes for each subunit and we find that rat liver AMPK‐α2 isoform catalytic subunit is associated with β1 and γ1 and not with β2 or γ2 subunit isoforms. The β1 and γ1 isoforms are also subunits of the α1 isoform. The sequence of cloned human AMPK‐β1 is 95% identical in amino acid sequence with rat β1. Human chromosomal localizations were determined for AMPK‐α1 (5p11‐p14), AMPK‐β1 (12q24.1‐24.3) and AMPK‐γ1 (12q12‐q14), respectively. |
| Databáze: |
Supplemental Index |
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