Schiff's base formation in the lens protein γ‐crystallin

Autor: Wistow, G., Alligood, J., Shinohara, T., Somers, R.
Zdroj: FEBS Letters; September 1983, Vol. 161 Issue: 2 p221-224, 4p
Abstrakt: Uniquely among the soluble lens‐specific proteins, γ‐crystallin is capable of binding the strongly chromophoric aldehyde retinal. a role for γ‐crystallin in protecting lens components from toxic aldehydes resulting from membrane oxidation is proposed and a molecular model of the probable interaction site is presented. The sequence of a tetrapeptide at this site is identical to that of the retinal binding site of bacteriorhodopsin.
Databáze: Supplemental Index