| Autor: |
Matsuda, Koichi, Kobune, Yoshiko, Noda, Chiseko, Ichihara, Akira |
| Zdroj: |
FEBS Letters; October 1994, Vol. 353 Issue: 3 p269-272, 4p |
| Abstrakt: |
Recently, we demonstrated that a DNA‐binding protein(s) is involved in transcriptional repression of the rat serine dehydratase gene in fetal liver. Here, we report that a GAT(A/T) motif is the target sequence for the DNA‐binding protein. By screening a fetal liver cDNA library, we isolated a rat homolog of GATA‐1. Rat GATA‐1 expressed as a GST‐fusion protein in E. colibound to the GAT(A/T) motif in the serine dehydratase gene. Northern analysis show that GATA‐1 and GATA‐4 mRNAs are expressed in fetal hepatocytes. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Plný text