Novel assay for the influenza virus M2 channel activity

Autor: Giffin, Kelleen, Rader, Randall K., Marino, Margaret H., Forgey, Robert W.
Zdroj: FEBS Letters; January 1995, Vol. 357 Issue: 3 p269-274, 6p
Abstrakt: The influenza A M2 ion channel was expressed and activity characterized in Xenopusoocytes. Based on the activation properties of the channels, a high throughput, non‐electrophysiological screening assay was developed in order to identify novel inhibitors of the channel. This will facilitate discovery of novel agents to treat influenza viral infections.
Databáze: Supplemental Index