| Autor: |
Abeyama, Kazuhiro, Kawano, Kazunori, Nakajima, Toshihiro, Takasaki, Ikuko, Kitajima, Isao, Maruyama, Ikuro |
| Zdroj: |
FEBS Letters; May 1995, Vol. 364 Issue: 3 p298-300, 3p |
| Abstrakt: |
The differentiation of PC12 cells to a neuron‐like morphology was induced by ionizing radiation in the presence of serum. This effect was detectable at 5 grays (Gy) and reached a maximum at 10–20 Gy. Increases in the DNA binding activity of nuclear factor κB (NF‐κB) and increased Interleukin 6 (IL‐6) mRNA levels were observed at a dose of 15 Gy. Neutralization of supernatant IL‐6 by the addition of anti‐IL‐6 antibody inhibited the neuronal differentiation and decreased cellular redox. Ionizing radiation and serum may act synergistically as neurotropic factors. |
| Databáze: |
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