| Autor: |
Johnson, W.Eustace B., Jones, Neil A., Rowlands, David C., Williams, Ann, Guest, Simon S., Brown, Geoffrey |
| Zdroj: |
FEBS Letters; May 1995, Vol. 364 Issue: 3 p309-313, 5p |
| Abstrakt: |
Stathmin is a cytosolic phosphoprotein that has an important but, as yet, undefined role in cell proliferation and differentiation. Induction of growth arrest and differentiation of HL60 cells to monocytes by phorbol 12‐myristate 13‐acetate is associated with rapid phosphorylation of the protein. Stathmin phosphorylation was not seen when HL60 cells were induced to differentiate to monocytes, by 1α,25‐dihydroxyvitamin D3, and to neutrophils, by all‐transretinoic acid and granulocyte colony stimulating factor. In all the above instances, stathmin expression was down‐regulated. Thus, increased stathmin phosphorylation is not required for cell growth arrest or differentiation or down‐regulation of stathmin expression. |
| Databáze: |
Supplemental Index |
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