| Autor: |
Horsten, Ursula, Schmitz-Van de Leur, Hildegard, Müllberg, Jürgen, Heinrich, Peter C., Rose-John, Stefan |
| Zdroj: |
FEBS Letters; February 1995, Vol. 360 Issue: 1 p43-46, 4p |
| Abstrakt: |
Gp130 is the signal transducing subunit of the interleukin‐6 receptor. Signaling is initiated by the complex formation of gp130 with IL‐6 bound to the IL‐6 receptor (IL‐6R). We have subdivided the extracellular domain of gp130 in two parts and expressed the mutant proteins as soluble IgG fusion proteins in COS‐7 cells. By studying the formation of the ternary complex we show that the membrane distal half of gp130 which contains a cytokine receptor domain is responsible for the interaction with the IL‐6/IL‐6R complex. Interestingly this is the same region which is believed to be involved in specific recognition of the related cytokines LIF, OM, and probably also of CNTF and IL‐11. |
| Databáze: |
Supplemental Index |
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