| Autor: |
Berndt, Norbert, Campbell, David G., Caudwell, F.Barry, Cohen, Philip, da Cruz e Silva, Edgar F., da Cruz e Silva, Odete B., Cohen, Patricia T.W. |
| Zdroj: |
FEBS Letters; November 1987, Vol. 223 Issue: 2 p340-346, 7p |
| Abstrakt: |
A 1.5 kb clone containing the full‐length coding sequence of a type‐1 protein phosphatase catalytic subunit has been isolated from a rabbit skeletal muscle cDNA library constructed in λgt10. The protein sequence deduced from the cDNA contains 311 residues and has a molecular mass of 35.4 kDa. A single mRNA species at 1.6 kb was visualized by Northern blotting. The type‐1 protein phosphatase was strikingly homologous to protein phosphatase 2A, 49% of the amino acids between residues 11 and 280 being identical. The first 10 and last 31 residues were dissimilar. Residues 1–101 of the type‐1 protein phosphatase also showed 21% sequence identity with a region of mammalian alkaline phosphatases. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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