| Autor: |
Abe, Junko, Morikawa, Makiko, Miyamoto, Katsuhito, Kaiho, Shin-ichi, Fukushima, Masafumi, Miyaura, Chisato, Abe, Etsuko, Suda, Tatsuo, Nishii, Yasuho |
| Zdroj: |
FEBS Letters; December 1987, Vol. 226 Issue: 1 p58-62, 5p |
| Abstrakt: |
Four analogues of vitamin D3with an oxygen atom in the side chain skeleton were synthesized to determine whether their differentiation‐inducing activity could be separated structurally from their activity to induce hypercalcemia. The order of the in vitro potency to reduce nitroblue tetrazolium in human myeloid leukemia cells (HL‐60) was 22‐oxa‐1α25‐(OH)2D3> 1α,25‐(OH)2D3> 20‐oxa‐1α,25‐(OH)2D3≒22‐oxa‐1α‐(OH) D3> 1α‐(OH)D3> 20‐oxa‐1α‐(OH)D3. 22‐Oxa‐1α,25‐(OH)2D3, was also about 10‐times more potent than 1α,25‐(OH)2D3in suppressing proliferation and inducing differentiation of mouse myelomonocytic leukemia cells (WEHI‐3), but the former was much weaker than the latter in inducing the release of 45Ca from prelabeled fetal mouse calvaria. These results suggest that the differentiation‐inducing activity of vitamin D compounds can be separated structurally from their activity to induce hypercalcemia. |
| Databáze: |
Supplemental Index |
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