| Autor: |
Penner, C.Gail, Davie, James R. |
| Zdroj: |
FEBS Letters; April 1994, Vol. 342 Issue: 3 p273-277, 5p |
| Abstrakt: |
The chicken erythrocyte transcription factor, GATA‐1, is associated with several non‐DNA binding proteins. We show that GATA‐1 multiprotein complexes exist in primitive and definitive erythrocytes. These complexes bind to GATA motifs of the p‐globin promoter and histone H5 enhancer with high affinity, and to the chicken β‐globin promoter specialized TATA element and enhancer GATA with low affinity. The low affinity β‐globin TATA element would allow basal transcription factors to displace the GATA‐1 multiprotein complex. Further, our results suggest that p‐globin promoter's low affinity Sp1 binding site and reduced levels of Sp1 in definitive cells prevent its expression in these cells. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Plný text