| Autor: |
Grinstein, Sergio, Vander Meulen, J., Furuya, W. |
| Zdroj: |
FEBS Letters; November 1982, Vol. 148 Issue: 1 p1-4, 4p |
| Abstrakt: |
Studies in model systems, as well as observations in intact cells, suggest that osmotic swelling of secretory granules is an essential step in exocytosis. A model is proposed whereby the low pH recorded in most secretory organelles could provide the driving force for granule swelling. The model assumes that during stimulation an exchange of H+for alkali cations is triggered across the granule membrane. The outgoing H+are rapidly replaced by the internal buffering capacity with a concomitant osmotic gain. The exchange is independent of anions and could be triggered by cytoplasmic Ca2+. The H+‐pump is responsible for the ΔpH but independent of the exchange mechanism. |
| Databáze: |
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