| Autor: |
Havelaar, Adrie C, de Gast, Izaäk L, Snijders, Saskia, Beerens, Cecile E.M.T, Mancini, Grazia M.S, Verheijen, Frans W |
| Zdroj: |
FEBS Letters; October 1998, Vol. 436 Issue: 2 p223-227, 5p |
| Abstrakt: |
Lysosomes are thought to play a role in various aspects of heavy metal metabolism. In the present study we demonstrate for the first time the presence of a heavy metal ion transport protein in the lysosomal membrane. Uptake of radioactive silver both in highly purified lysosomal membrane vesicles and in purified intact lysosomes showed the typical kinetics of a carrier‐mediated process. This transport was stimulated by ATP hydrolysis, and showed specificity for Ag+, Cu2+, and Cd2+. All biochemical properties of this lysosomal metal ion transporter could classify it as a heavy metal transporting P‐type ATPase. Long Evans Cinnamon (LEC) rats, an animal model for the copper transport disorder Wilson disease, showed normal lysosomal silver transport. |
| Databáze: |
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