Biogenesis of liver δ‐aminolevulmate synthase

Autor: Friedland, David M., Ades, Ibrahim Z.
Zdroj: FEBS Letters; October 1985, Vol. 191 Issue: 1 p117-120, 4p
Abstrakt: In primary cultures of chick embryo hepatocytes pulse labeled with [35S]methionine, immunochemical analyses indicated that adenosine 3':5'‐cyclic monophosphate (cAMP) did not affect either the rate of production or the maturation of δ‐aminolevulinate synthase (ALA synthase). In addition, allylisopropylacetamide caused a slight drop in intracellular cAMP while testosterone caused the levels of cAMP to rise to 260% of the basal levels measured in hepatocytes in culture. Thus the results of this study did not indicate a direct short‐term role for cAMP in the regulation of production of ALA synthase.
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