The mechanisms of the cyclic AMP‐dependent regulation of the enzymes of the 2′,5′‐oligoadenylate system

Autor: Itkes, A.V., Turpaev, K.T., Kartasheva, O.N., Tunitskaya, V.L., Kafiani, C.A.
Zdroj: FEBS Letters; June 1984, Vol. 171 Issue: 1 p101-105, 5p
Abstrakt: The cAMP‐dependent induction of 2,5‐oligoadenylate (2‐5A) synthetase and cAMP‐dependent inhibition of 2‐5A phosphodiesterase are shown. Variations in activities of cAMP‐dependent protein kinase and the enzymes of 2‐5A metabolism in the cells deepening into the resting state were found to be compatible with the above finding. A scheme of coordinated action of cAMP and 2‐5A is proposed.
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