| Autor: |
Pailler-Rodde, I., Garcin, H., Higueret, P., Begueret, J. |
| Zdroj: |
FEBS Letters; September 1991, Vol. 289 Issue: 1 p33-36, 4p |
| Abstrakt: |
Vitamin A is required for normal growth and development and synergistically acts with thyroid hormones in these processes. Effects of retinol dietary intake (0, 5, 50 U retinol/g food) on the triiodothyronine (T3) nuclear receptor were examined in rat liver. Properties of this receptor have been investigated by an in vitro binding method. The amount of c‐erb‐A mRNA has been deduced by reverse transcription and amplification methods (PCR). Results show that both retinol deficiency and excess leads to a reduced amount of c‐erb‐A mRNA and to a decreased T3 binding capacity, suggesting that retinol, or retinoic acid which is its natural metabolite, contributes to the regulation of the T3 nuclear receptor properties. |
| Databáze: |
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